Though the LORD is great, he cares for the humble,
But he keeps his distance from the proud.
(Psalm 138:6 NLT)
In his book Mere Christianity, C. S. Lewis devotes a chapter to the great sin, pride or self-conceit, which he refers to as the utmost evil, because it “leads to the complete anti-God state of mind” and many other sins.
Opposite of pride is humility, and God responds favorably to humility. He sets Himself against the proud that think they have no need of Him. When we are humble, He is quick to renew our strength and help us against those who would harm us.
"Humility is not thinking less of yourself, it's thinking of yourself less."
- C. S. Lewis